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Variable Data-Independent Acquisition (vDIA) Delivers High Selectivity and Sensitivity in Combined Targeted and Untargeted Analyses for Small Molecules Be the first to rate this application

variable dataindependent acquisition vdia delivers high selectivity sensitivity combined targeted untargeted analyses for small molecules
# Compound Name Compound Class
1 Abamectin Veterinary Drug
2 Amoxicillin Veterinary Drug
3 Ampicillin Veterinary Drug
4 Cefalexin Veterinary Drug
5 Cefalonium Veterinary Drug
6 Cefaperazone Veterinary Drug
7 Cefapirim Veterinary Drug
8 Cefquinome Veterinary Drug
9 Chlorotetracycline Veterinary Drug
10 Ciprofloxacin Veterinary Drug
11 Cloxacillin Veterinary Drug
12 Danofloxacin Veterinary Drug
13 Dapsone Veterinary Drug
14 Difloxacin Veterinary Drug
15 Dimetridazol Veterinary Drug
16 Doramectin Veterinary Drug
17 Doxycyclin Veterinary Drug
18 Enrofloxacin Veterinary Drug
19 Eprinomectin Veterinary Drug
20 Erythromycine Veterinary Drug
21 Flumequine Veterinary Drug
22 Ipronidazol-OH Veterinary Drug
23 Marbofloxacine Veterinary Drug
24 Metronidazole Veterinary Drug
25 Metronidazole-OH Veterinary Drug
26 Moxidectin Veterinary Drug
27 Nafcillin Veterinary Drug
28 Oxacillin Veterinary Drug
29 Penicillin G Veterinary Drug
30 Penicillin V Veterinary Drug
31 Ronidazol Veterinary Drug
32 Sarafloxacine Veterinary Drug
33 Sulfadiazine Veterinary Drug
34 Sulfadimethoxin Veterinary Drug
35 Sulfadimidin/Sulfamethazine Veterinary Drug
36 Sulfadoxin Veterinary Drug
37 Sulfamerazin Veterinary Drug
38 Sulfamethoxazole Veterinary Drug
39 Sulfamethoxypyridazine Veterinary Drug
40 Sulfathiazole Veterinary Drug
41 Tetracycline Veterinary Drug
42 Thiamphenicol Veterinary Drug
43 Trimethoprim Veterinary Drug
44 Tylosine Veterinary Drug

Description

Forty-four multi-class veterinary drugs of known concentrations were employed to demonstrate how the use of a generic variable data-independent acquisition (vDIA) method with wide MS/MS precursor isolation windows achieves sensitivity and selectivity comparable to data-dependent MS2 acquisition (using narrow isolation windows) in quantitative and qualitative small molecule applications. In addition, a full record of MS and MS/MS data for the measured sample fit for non-targeted and unknown screening purposes is delivered. vDIA is not available in the United States of America
Market: Food and Beverage
Keywords: Q Exactive Focus MS, Veterinary drugs, vDIA, Small molecule HRAM quantitation, Small molecule HRAM screening
Matrix: Foods, Plasma
Author: Olaf Scheibner, Markus Kellmann, Charles Yang, Maciej Bromirski
Affiliation: Thermo Fisher Scientific
Uploaded on 2/23/2016.

For Research Use Only. Not for use in diagnostic procedures.

Tags

Food Food and Beverage HRAM LCMSMS plasma Q Exactive Focus MS Quantitation screening vDIA Veterinary Drug
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