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Variable Data-Independent Acquisition (vDIA) Delivers High Selectivity and Sensitivity in Combined Targeted and Untargeted Analyses for Small Molecules Be the first to rate this application

variable dataindependent acquisition vdia delivers high selectivity sensitivity combined targeted untargeted analyses for small molecules


Forty-four multi-class veterinary drugs of known concentrations were employed to demonstrate how the use of a generic variable data-independent acquisition (vDIA) method with wide MS/MS precursor isolation windows achieves sensitivity and selectivity comparable to data-dependent MS2 acquisition (using narrow isolation windows) in quantitative and qualitative small molecule applications. In addition, a full record of MS and MS/MS data for the measured sample fit for non-targeted and unknown screening purposes is delivered. vDIA is not available in the United States of America
Market: Food and Beverage
Keywords: Q Exactive Focus MS, Veterinary drugs, vDIA, Small molecule HRAM quantitation, Small molecule HRAM screening
Matrix: Foods, Plasma
Author: Olaf Scheibner, Markus Kellmann, Charles Yang, Maciej Bromirski
Affiliation: Thermo Fisher Scientific
Uploaded on 2/23/2016.

For Research Use Only. Not for use in diagnostic procedures.