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Variable Data-Independent Acquisition (vDIA) Delivers High Selectivity and Sensitivity in Combined Targeted and Untargeted Analyses for Small Molecules
Description
Forty-four multi-class veterinary drugs of known concentrations were employed to demonstrate how the use of a generic variable data-independent acquisition (vDIA) method with wide MS/MS precursor isolation windows achieves sensitivity and selectivity comparable to data-dependent MS2 acquisition (using narrow isolation windows) in quantitative and qualitative small molecule applications. In addition, a full record of MS and MS/MS data for the measured sample fit for non-targeted and unknown screening purposes is delivered. vDIA is not available in the United States of America| Market: | Food and Beverage |
| Keywords: | Q Exactive Focus MS, Veterinary drugs, vDIA, Small molecule HRAM quantitation, Small molecule HRAM screening |
| Matrix: | Foods, Plasma |
| Author: | Olaf Scheibner, Markus Kellmann, Charles Yang, Maciej Bromirski |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
