Fast and Easy separation of 23 drugs of abuse, including the adequate and stable resolution of isobaric opioids from human urine. The new Thermo Scientific™ Accucore™ Biphenyl solid core column is used in combination with the Thermo Scientific™ Horizon™ UHPLC system and Thermo Scientific™ TSQ Quantiva™ MS/MS system.
To describe a fast and reproducible optimization procedure for the isolation of opioids from human urine utilizing solid phase extraction (SPE). Subsequent analysis was carried out with liquid chromatography separation coupled to triple quadrupole mass spectrometry detection (LC-MS/MS).
Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
Forensic toxicologists need an economical instrument capable of both screening a large number of compounds and quantifying smaller panels to industry-established limits. Here we present a method for quantitation of six opiates - morphine, codeine, hydromorphone, hydrocodone, oxymorphone, and oxycodone - in human urine down to low ng/mL levels. This work was performed on a Q Exactive Focus hybrid quadrupole Orbitrap mass spectrometer. For forensic use only.
Forensic laboratories perform bulk substance identification to support investigations in cases involving possession, trafficking, and manufacturing of illicit drugs. A variety of analytical techniques can be used, but mass spectrometry provides methodologies that produce rapid and confident results. We evaluated two analytical workflows using a DART (Direct Analysis in Real Time) ion source coupled to a LTQ XL ion trap mass spectrometer and a Q Exactive Focus hybrid quadrupole- Orbitrap MS. Pharmaceutical pills were analyzed to demonstrate method performance. For forensic use only.
