To develop a robust, sensitive, reliable, and reproducible PaperSpray-mass spectrometry workflow for detection of illicit drugs in blood for clinical research and forensic toxicology using the Thermo Scientific™ TSQ Altis™ mass spectrometer connected with the Thermo Scientific™ VeriSpray™ PaperSpray system
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for assay and organic impurities analysis of buprenorphine and naloxone sublingual tablets. The analysis was performed on a Thermo Scientific Syncronis Phenyl HPLC column using the method described in the USP 42. The observed results met the system suitability criteria for both assay and organic impurities test parameters.
Fast and Easy separation of 23 drugs of abuse, including the adequate and stable resolution of isobaric opioids from human urine. The new Thermo Scientific™ Accucore™ Biphenyl solid core column is used in combination with the Thermo Scientific™ Horizon™ UHPLC system and Thermo Scientific™ TSQ Quantiva™ MS/MS system.
Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
Due to its increased abuse, forensic and testing labs test routinely for the presence of buprenorphine and its metabolite norbuprenorphine. To reduce their case backlog, these labs need cost-efficient analytical tests on hundreds of samples. We developed a high-throughput screening and quantitation LC-MS/MS method in which urine samples are quickly prepared and analyzed by a short chromatographic method implemented on a four-channel LC-MS system for improved productivity. For forensic use only.
