The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ TSQ Quantis™ Plus mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Stellar™ mass spectrometer is used for the separation and detection of drugs of abuse in oral fluid matrix. The SPE extraction uses XTR tips with mixed mode SCX/WAX chemistry. Using a Thermo Scientific™ Accucore™ Biphenyl column with a total run time of 4.5 minutes, all isomers were separated, including methamphetamine / phentermine and hydromorphone / morphine. The method includes both CID (resonance-type, unique to ion traps) and HCD (beam-type) activations for more optimized fragmentation.
The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Orbitrap Exploris™ mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
The Thermo Scientific™ Vanquish™ Flex UHPLC coupled with the Thermo Scientific™ TSQ Certis™ mass spectrometer is used for the separation and detection of drugs of abuse in whole blood. The method features protein precipitation and filtration extraction protocol using ToT technology. Using a Thermo Scientific™ Accucore™ Biphenyl column with a total run time of 4.5 minutes, all isomers were separated, including methamphetamine / phentermine and hydromorphone / morphine / norcodeine. With >900 SRMs per second and sub 5 ms polarity switching, this method offers the speed and sensitivity required.
To develop a robust, sensitive, reliable, and reproducible PaperSpray-mass spectrometry workflow for detection of illicit drugs in blood for clinical research and forensic toxicology using the Thermo Scientific™ TSQ Altis™ mass spectrometer connected with the Thermo Scientific™ VeriSpray™ PaperSpray system
