Thermo Scientific AppsLab Library: A ready-to-run workflow for quantitating 80 drugs of abuse in whole blood with the TSQ Certis Triple Quadrupole MS

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A ready-to-run workflow for quantitating 80 drugs of abuse in whole blood with the TSQ Certis Triple Quadrupole MS Be the first to rate this application

Combined Extracted Ion Chromatogram

TSQ Certis MS

Extraction Protocol

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Description

The Thermo Scientific™ Vanquish™ Flex UHPLC coupled with the Thermo Scientific™ TSQ Certis™ mass spectrometer is used for the separation and detection of drugs of abuse in whole blood. The method features protein precipitation and filtration extraction protocol using ToT technology. Using a Thermo Scientific™ Accucore™ Biphenyl column with a total run time of 4.5 minutes, all isomers were separated, including methamphetamine / phentermine and hydromorphone / morphine / norcodeine. With >900 SRMs per second and sub 5 ms polarity switching, this method offers the speed and sensitivity required.

Market:	Clinical Research
Keywords:	drugs of abuse, Toxicology, clinical, Forensics, whole blood
Matrix:	whole blood

Uploaded on 3/5/2026.

For Research Use Only. Not for use in diagnostic procedures.