Thermo Scientific AppsLab Library: Utilizing HRAM Orbitrap mass spectrometry to quantitate 106 drugs of abuse in urine

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Combined Extracted Ion Chromatogram

Gradient (Note: curve of 7)

Isomer Separation

Orbitrap Exploris 120

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Description

The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Orbitrap Exploris™ mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.

Market:	Clinical Research
Keywords:	drugs of abuse, Toxicology, Urine, clinical, Forensics
Matrix:	Urine

Uploaded on 3/5/2026.

For Research Use Only. Not for use in diagnostic procedures.