The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ TSQ Quantis™ Plus mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
The Thermo Scientific™ Vanquish™ Horizon UHPLC coupled with the Thermo Scientific™ Orbitrap Exploris™ mass spectrometer is used for the separation and detection of drugs of abuse in urine matrix. The SPE extraction uses Thermo Scientific™ SOLAμ™ SCX SPE plates for minimal sample and solvent volumes. Using a Thermo Scientific™ Accucore™ C18+ column with a total run time of 7 minutes, all isomers were separated including codeine / hydrocodone, and hydromorphone / morphine / norhydrocodone. The method includes 106 of the most tested drugs of abuse for easy adaption to customer labs.
Demonstrate the ease of implementation and processing of a full method validation that Chromeleon CDS performs with the eWorkflows based on the ICH guidelines.
This application demonstrates the straightforward transfer of an analytical HPLC method from an Agilent 1260 Infinity instrument to a Thermo Scientific UltiMate 3000 HPLC system and a Thermo Scientific Vanquish Flex UHPLC system with the example of a USP derived assay for the analysis of acetaminophen and its impurities.
This application demonstrates the straightforward transfer of an analytical HPLC method from a Thermo Scientific UltiMate 3000 HPLC system to a Thermo Scientific Vanquish Flex UHPLC system demonstrated with a USP derived assay for the analysis of acetaminophen and its impurities.
