The integration of Thermo Scientific Vanquish HPLC and UHPLC Systems with an aseptic autosampler enables automated online sample delivery and analysis for pseudo real-time monitoring of protein titer and critical quality attributes (CQAs) during upstream process development.
Demonstrate the applicability of NP-HPLC-CAD for characterizing PDMS composition in silicone oils.
This white paper investigates the impact of vial surface chemistry on analyte recovery in LC and LC-MS workflows, with a focus on adsorption-sensitive biomolecules at low concentrations. It compares different vial materials using representative analytes—including peptides, proteins and monoclonal antibodies—to evaluate how nonspecific binding affects recovery and reproducibility. The study demonstrates that selecting an appropriate vial surface can significantly reduce analyte loss and improve confidence in results, providing practical guidance for optimizing sample handling in routine work.
Natural gas, an important energy source, is often compressed into liquid for easier transportation. Combustion-IC (C-IC) has been previously demonstrated as an ideal approach to eliminate the sample matrix and increase sample homogeneity for various sample matrices. Additionally, C-IC is recognized as an ASTM standardized method (D7994) to determine halogens and sulfur in LPG. Here, we determine halides and sulfur species in LPG using C-IC, leveraging advances in the Thermo Scientific™ Cindion™ C-IC system using the Thermo Scientific™ Cindion™ LPG/Gas Module with built-in safety features.
Analysis of large RNA using an ion-pair reversed-phase method on a SurePac Oligo RP MDi column<enter next 255 characters of description><enter final 90 characters of description>
