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A Sensitive and Efficient Method to Analyze THC and THCCOOH in Oral Fluid Using LC-MS/MS in Forensic Toxicology Laboratories
Description
The Substance Abuse and Mental Health Services Administration (SAMHSA) lists delta9-tetrahydrocannabinol (THC) as the only target analyte for detection of cannabis use in oral fluid at 2 ng/mL confirmation cutoff concentration. In this study, we developed a sensitive and efficient method for simultaneous determination of THC and THCCOOH in OF. Both analytes were extracted using a simple and fast SPE method without pre-conditioning, evaporation, or reconstitution. THCCOOH was detected with high sensitivity (LOQ 10 pg/mL), and no derivatization procedure was required. For forensic use only.| Market: | Forensics; Toxicology |
| Keywords: | Accucore, SPE, THCCOOH, THC, SOLAµ, Cannabinoid, TSQ Quantiva MS, Oral Fluid, UltiMate 3400RS |
| Matrix: | Oral fluids |
| Author: | Xiaolei Xie, Thomas Carrell, Marta Kozak |
| Affiliation: | Thermo Fisher Scientific |
