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AN1108: Comparison of Soxhlet and Accelerated Solvent Extraction for Leachable and Extractable Analysis of Packing Material
Description
This application note compares Soxhlet and accelerated solvent extraction techniques in packing material extractable studies. A polypropylene pill bottle and a transdermal patch pouch were extracted with 2-propanol and n-hexane using the Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor system and Soxhlet, respectively. The extracts were analyzed using a Thermo Scientific™ Dionex™ UltiMate™ 3000 HPLC system coupled with a Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass spectrometer.| Market: | BioPharma; Pharma |
| Keywords: | HPLC, ASE, ASE 350, Packing Material, Transdermal patch pouch, Polypropylene (PP) pill bottle |
| Matrix: | Drug packaging |
| Author: | Hua Yang Kate Comstock and Linda Lopez |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
