AN327: Extraction of Nitroglycerin from Transdermal Patches by Accelerated Solvent Extraction

Instrument Type: Automated Sample Prep

Accelerated solvent extraction is an extraction method that significantly streamlines sample preparation. Solvent is pumped into an extraction cell containing the sample, which is then brought to an elevated temperature and pressure. The entire extraction process is fully automated and performed in minutes for fast and easy extraction with low solvent consumption. The work reported here was undertaken to investigate the use of accelerated solvent extraction for the extraction of nitroglycerin from prototype transdermal matrix patches.

AN1108: Comparison of Soxhlet and Accelerated Solvent Extraction for Leachable and Extractable Analysis of Packing Material

Instrument Type: HPLC

This application note compares Soxhlet and accelerated solvent extraction techniques in packing material extractable studies. A polypropylene pill bottle and a transdermal patch pouch were extracted with 2-propanol and n-hexane using the Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor system and Soxhlet, respectively. The extracts were analyzed using a Thermo Scientific™ Dionex™ UltiMate™ 3000 HPLC system coupled with a Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass spectrometer.