AN1108: Comparison of Soxhlet and Accelerated Solvent Extraction for Leachable and Extractable Analysis of Packing Material

Instrument Type: HPLC

This application note compares Soxhlet and accelerated solvent extraction techniques in packing material extractable studies. A polypropylene pill bottle and a transdermal patch pouch were extracted with 2-propanol and n-hexane using the Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor system and Soxhlet, respectively. The extracts were analyzed using a Thermo Scientific™ Dionex™ UltiMate™ 3000 HPLC system coupled with a Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass spectrometer.