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AN190: Determination of Sulfate Counter Ion and Anionic Impurities in Aminoglycoside Drug Substances by Ion Chromatography with Suppressed Conductivity Detection Be the first to rate this application

an190 determination sulfate counter ion anionic impurities aminoglycoside drug substances by ion chromatography with suppressed conductivity detection


Many drug substances are in salt forms to promote solubility, stability, and bioavailability. It is important to accurately determine the concentration of the counter ions to establish the correct molecular mass, the stoichiometric relationship and the completeness of salt formation. This application note describes the linearity, detection limits, precisions, and recoveries using anion-exchange chromatography with an electrolytically-generated potassium hydroxide eluent and IonPac AS18 column for the determination of sulfate counter ions and impurities in aminoglycosides.
Market: Pharma
Keywords: Aminoglycoside, Anion-exchange, Anions, Chloride, Counter ion, Drug, Ion chromatography, IonPac AS18, Pharmaceutical, Phosphate, RFIC, Sulfate, Suppressed conductivity
Matrix: Drug
Uploaded on 8/21/2015.

For Research Use Only. Not for use in diagnostic procedures.