AU167: Determination of Tobramycin in Crude and In-Process Production Samples During Manufacturing Using HPAE-IPAD

Instrument Type: IC

This update describes how tobramycin and its typical impurities can be determined in manufacturing process matrices using the same HPAE-IPAD method described in AN 61. The same method is used to assay tobramycin that is intentionally degraded, demonstrating its suitability as a stability indicating method. An ICS-6000 can be used for this application.

AN66: Determination of Neomycin B and Impurities Using HPAE-IPAD

Instrument Type: IC

In this application note, we combine the CarboPac PA1, an eluent generator with CR-ATC, and disposable Au working electrodes to demonstrate an improved HPAE-PAD technology for Neomycin B purity analysis and its determination in Neosporin topical ointment, a complex over-the-counter pharmaceutical formulation.

AN61: Determination of Tobramycin and Impurities Using HPAE-PAD

Instrument Type: IC

In this application note, we combine the CarboPac PA1, eluent generator with CR-ATC, and disposable Au working electrodes to demonstrate an improved HPAE-PAD technology for tobramycin purity analysis.