Simultaneous, Fast Analysis of Melamine and Analogues in Pharmaceutical Components Using Q Exactive - Benchtop Orbitrap LC-MS/MS

Instrument Type: LCMSMS

We demonstrated a simple workflow for the simultaneous analysis of melamine and analogues in pharmaceutical components using a Q Exactive benchtop Orbitrap mass spectrometer. The sensitive, simple and robust method employed the Thermo Fisher Scientific Q Exactive high resolution Orbitrap mass spectrometry coupled with UHPLC and HILIC mode chromatographic separation. Simultaneous detection and quantification of melamine and its analogues in Albumin and Guar gum were achieved with a high degree of confidence.

Measuring Phytosterols in Health Supplements by LC/MS

Instrument Type: LCMS

Plant sterols, phytosterols, are claimed to help lower cholesterol levels in humans. In the year 2000, the United States Food & Drug Administration (US FDA) approved a health claim relating phytosterol ester or phytostanol ester consumption to reduced risk for coronary heart disease. Thus, there is increased interest in qualitative and quantitative analysis of phytosterols in food products. Phytosterols are typically measured by gas chromatography after derivatization. In this study, phytosterols were injected onto an LC-MS for direct analysis.

Analysis of Nine N-Nitrosamines Using Liquid Chromatography-High-Resolution, Accurate-Mass Mass Spectrometry

Instrument Type: LCMS

N-nitrosamines present high mutagenic and carcinogenic potential. They or their precursors occur in a wide variety of foods and natural and manufactured products. An analysis method for nine N-nitrosamines based on ultra-high performance liquid chromatography combined with high-resolution, accurate-mass (HRAM) mass spectrometry is presented here.