EP 8.0 monograph: impurity determination of sulfadiazine using a polar-embedded HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of sulfadiazine and its impurities . The separation was performed on a Thermo Scientific Acclaim Polar Advantage II (PA2) HPLC column using the method described in the EP 8.0 monograph. The results obtained for resolution and relative retention time (RRT) exceeded the criteria stated in the EP. Resolution between impurity B and impurity A was 2.8 (EP criteria of not less than 2.0) and tailing factor for sulfadiazine peak was 0.8 (EP criteria of NMT 2.0).

Enhanced gradient resolution of sulfa drugs

Instrument Type: HPLC

The Thermo Scientific HPLC system is applied for the analysis of sulfa drugs. The separation is performed using a Thermo Scientific Acclaim PolarAdvantage column, with UV detection at 254 nm.

Rapid analysis of sulfonamide antibiotics using a Thermo Scientific Acclaim 120 C18 RSLC column

Instrument Type: HPLC

The Thermo Scientific UltiMate 3000 RS HPLC system is applied for the determination of sulfonamide antibiotics. The separation is performed on a Thermo Scientific Acclaim 120 C18 RSLC column, with UV detection at 265 nm.

High resolution analysis of sulfonamide antibiotic residues in milk using a Thermo Scientific Acclaim 120 C18 column

Instrument Type: HPLC

The Thermo Scientific HPLC system is applied for the determination of sulfonamide antibiotic residues in milk. The separation is performed on a Thermo Scientific Acclaim 120 C18 HPLC column, with UV detection at 265 nm.