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Displaying 1-5 of 12 results for Tag: Statin

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Related substance and assay analysis of Rosuvastatin as per BP/EP methods using an Acclaim C18 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of related substance and assay of Rosuvastatin as per BP/EP. The analysis was performed on a Thermo Scientific Acclaim 120 C18 HPLC column using the method described in the BP/EP monograph. The results obtained were found to be within acceptance criteria as stated in the monograph. Resolution between Rosuvastatin and Impurity B was found to be 3.75 (criteria is not less than 2.0).

Rapid screening method for statins using an advanced UHPLC column and system.

Instrument Type: UHPLC

To provide an application for the analysis of statins using the Thermo Scientific™ Hypersil GOLD VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish H™ UHPLC system, exploiting the non-linear gradient capability of the systemDemonstrate the opportunity for increased throughput by operating at higher flow rates and backpressures

USP 38 monography - assay of lovastatin related compound A using a C8 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the assay analysis of lovastatin related compound-A. The analysis was performed on a Thermo Scientific Syncronis C8 HPLC column using the method described in the USP 38 monograph. Resolution between lovastatin and lovastatin related compound A was 10.9 (exceeded USP criteria of NLT 6.0). Relative retention time of lovastatin related compound A with respect to lovastatin was 1.39 (met USP criteria of about 1.3). The % RSD for replicate injection of standard solution was 0.9% (exceed USP criteria not more than 5.0%).

Rapid screening method for statins using an advanced solid core UHPLC column and system combination

Instrument Type: UHPLC

Demonstration of the advantages of using the Thermo Scientific Accucore Vanquish C18+, 1.5 μm column and Thermo Scientific Vanquish UHPLC system for the fast analysis of statins. The advanced capabilities of the Vanquish UHPLC system allow the Accucore Vanquish columns to be operated at high flow rates that enable development of rapid analytical methods while maintaining high performance.

Accurate determination of atorvastatin impurities using reversed-phase HPLC-UV

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of atorvastatin impurities. The separation was performed on a Thermo Scientific Accucore aQ HPLC column using a reversed-phase method with UV detection at 254 nm.