AN117: Quantification of Carbohydrates and Glycols in Pharmaceuticals - Alditols and Small Carbohydrates Method

Instrument Type: IC

Two oral, over-the-counter medications were evaluated as representative pharmaceutical products. A cough suppressant and a multisymptom cold/flu medication were chosen because they contain a complex mixture of simple sugars, glycols,and sugar alcohols. These carbohydrates and glycols are also commonly found in other medications. This method uses the CarboPac MA1 column to retain and separate the target analytes.

AN117: Quantification of Carbohydrates and Glycols in Pharmaceuticals - Small Sugars

Instrument Type: IC

This application note describes the use of three different anion-exchange columns with amperometric detection to analyze common simple sugars, sugar alcohols, and glycols in pharmaceutical formulations. This record describes a method using the CarboPac PA10 column to determine some of the target carbohydrates. The reader is advised to review TN21 for updated waveform information.

AN117 - Quantification of Carbohydrates and Glycols in Pharmaceuticals - Glycols Method

Instrument Type: IC

This application note describes the use of three different anion-exchange columns with amperometric detection to analyze common simple sugars, sugar alcohols, and glycols in pharmaceutical formulations. The method in this entry shows how to determine glycols using ion-exclusion chromatography on Dionex ICE-AS1 column.

AN164: Assay for Citrate and Phosphate in PharmaceuticalFormulations Using Ion Chromatography

Instrument Type: IC

In this application, we report on the validation of an IC method for the determination of phosphate and total citric acid in pharmaceutical formulations with a hydroxide-selective, anion-exchange column and suppressed conductivity detection. The method incorporates an electrolytic eluent generator to automatically produce a simple isocratic potassium hydroxide eluent, allowing the separation of phosphate and citrate on an Thermo Scientific Dionex IonPac AS11 column in less than 10 min.