We present the reliable and accurate quantitative analysis of contaminants at the pg/mL level in drinking water using the Thermo Scientific EQuan MAX Plus LC-MS system coupled to the Thermo Scientific TSQ Endura triple quadrupole mass spectrometer. Excellent reproducibility was shown for the target compounds in tap water using 1 mL injections at 0.37× maximum effluent concentration.

The Thermo Scientific Dionex UltiMate 3000 system is applied for the fast separation of the impurities present in the nonsteroidal anti-inflammatory drug aceclofenac in solid dosage formulation. The separation was performed in less than 16 minutes using a Thermo Scientific Syncronis C18 5 µm column with UV detection at 275 nm.

The Thermo Scientific HPLC system is applied for the determination of fenoprofen. The separation was performed on a Thermo Scientific Accucore RP-MS column, with a run time of 7 minutes and UV detection at 272 nm. The method of analysis is based on the USP monograph, and was scaled down by using an in-house method transfer calculator.

The separation of acidic and neutral drugs was successfully achieved on the Thermo Scientific Accucore C18 column, providing an excellent choice for the analysis of these drugs giving excellent retention time reproducibility and resolution.

The separation of three nonsteroidal anti-inflamatory drugs (NSAIDs) is performed on a Thermo Scientific Acclaim PolarAdvantage II (PA2) 5 µm column with a run time of less than 12 minutes.