Forensic Screening for Drugs in Urine Using High-Resolution MS/MS Spectra and Simplified High-Performance Screening Software

Instrument Type: LCMSMS

Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.

Quantitation of 122 Drugs in Urine by Triple Quadrupole Mass Spectrometry

Instrument Type: LCMSMS

Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.

Rapid analysis of barbiturates on a Thermo Scientific UltraFast GC column

Instrument Type: GC

The Thermo Scientific Trace Ultra GC system (with UltraFast configuration) is applied for the analysis of barbiturates. The separation is performed on a Thermo Scientific UltraFast UFC-5 column, with flame ionization detection.

Fast analysis of barbiturates using a Thermo Scientific Acclaim 120 C18 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex HPLC system is applied for the analysis of barbiturates. The separation is performed using a Thermo Scientific Acclaim 120 C18 column, with UV detection at 210nm.