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Displaying 1-5 of 12 results for: lc-ms

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Complementary analysis in a biopharmaceutical research laboratory with a 2D-LC-MS instrument for flexible operation

Instrument Type: LCMS

The application note describes an efficient approach for identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC-MS in a top-down experiment. In addition the Thermo Scientific™ Simple Switch™ technology enables the instrument to be used in multi heart-cut 2D-LC-MS, 1D-LC-MS, or Dual 1D-LC mode for the most flexible equipment and lab space utilization and maximum MS productivity.

Increase sensitivity in UHPLC-MS analysis by minimizing post-column dispersion

Instrument Type: LCMS

Reduce post-column dispersion with small ID capillaries for fast gradient UHPLC-MS methods using sub-2 μm particle next-generation columns

Forced-degradation evaluation of erythromycin by HPLC and single quadrupole mass spectrometry

Instrument Type: LCMS

Simple stability-indicating LC-MS method for erythromycin. Compare the impurity profiles of an erythromycin reference standard with stressed analyte.

Impurity profiling of the synthetic peptide LL-37 using high-performance liquid chromatography with combined UV and single quadrupole mass spectrometric detection

Instrument Type: LCMS

Leveraging UV detection for the determination of the impurity levels and mass detection for identification of the active pharmaceutical ingredient (API) and other product related impurities using a rapid method for synthetic peptide impurity profiling

Oligonucleotide characterization for quality control and increased productivity by single quadrupole mass spectrometer with extended mass range

Instrument Type: LCMS

We demonstrate increased productivity in the analysis of synthetic oligonucleotides between 29 and 40 base pairs in length by incorporating the Thermo Scientific ISQ EM single quadrupole mass spectrometer into a UV-based quality control method