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Complementary analysis in a biopharmaceutical research laboratory with a 2D-LC-MS instrument for flexible operation Be the first to rate this application

complementary analysis a biopharmaceutical research laboratory with a 2dlcms instrument for flexible operation


The application note describes an efficient approach for identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC-MS in a top-down experiment. In addition the Thermo Scientific™ Simple Switch™ technology enables the instrument to be used in multi heart-cut 2D-LC-MS, 1D-LC-MS, or Dual 1D-LC mode for the most flexible equipment and lab space utilization and maximum MS productivity.
Market: BioPharma
Keywords: Size exclusion chromatography, Biopharmaceutical, mass spectrometry, reversed-phase chromatography, 2D-LC, Orbitrap Fusion Tribrid Mass Spectrometer, therapeutic proteins, Vanquish Duo for Dual LC, Vanquish Loop Heart-Cut 2D-LC system, Vanquish Simple Switch 2D-LC system
Author: Maria Grübner
Affiliation: Thermo Fisher Scientific, Germering, Germany
Uploaded on 9/6/2021.