Rate
Ask the Expert
Suggest an Application
Add to Favorites
Download eWorkflow
Tell a Friend
PrintFind methods for your needs
Complementary analysis in a biopharmaceutical research laboratory with a 2D-LC-MS instrument for flexible operation
Description
The application note describes an efficient approach for identity confirmation of protein-based impurities of a therapeutic protein by multi heart-cut 2D-LC-MS in a top-down experiment. In addition the Thermo Scientific™ Simple Switch™ technology enables the instrument to be used in multi heart-cut 2D-LC-MS, 1D-LC-MS, or Dual 1D-LC mode for the most flexible equipment and lab space utilization and maximum MS productivity.| Market: | BioPharma |
| Keywords: | Size exclusion chromatography, Biopharmaceutical, mass spectrometry, reversed-phase chromatography, 2D-LC, Orbitrap Fusion Tribrid Mass Spectrometer, therapeutic proteins, Vanquish Duo for Dual LC, Vanquish Loop Heart-Cut 2D-LC system, Vanquish Simple Switch 2D-LC system |
| Author: | Maria Grübner |
| Affiliation: | Thermo Fisher Scientific, Germering, Germany |
