Simple and Rapid Analysis of Chloramphenicol in Milk by LC-MS/MS
Instrument Type: LCMSMS
Chloramphenicol (CAP) is a broad-spectrum antibiotic with historical veterinary uses in all major food-producing animals. It has serious side effects on humans that may cause aplastic anemia, and suspected carcinogen effect. Though banned for use in all food-producing animals by the EU, USA and Canada, residues of CAP at unacceptable levels continue to be found in food imports. We describe a simple sample preparation procedure followed by a high-speed LC separation and detection by a triple quadrupole MS operated in SRM mode and validation per European Commission Decision 2002/657/EC.