The aim of this study is to demonstrate the suitability of the Thermo Scientific™ TRACE™ 1610 GC series combined with the Thermo Scientific™ TriPlus™ RSH SMART autosampler for characterization of residual methanol in biodiesel according to the EN 14110:2020 method.
The aim of this work was to develop a rapid, cost-effective, modified USP <467> HS-GC-FID method for residual solvent determination in pharmaceutical products using the Thermo Scientific™ TriPlus™ 500 Headspace Autosampler and nitrogen as carrier gas.
In this technical note, a Thermo Scientific™ TriPlus™ 500 Headspace Autosampler was coupled to a Thermo Scientific™ TRACE™ 1310 Gas Chromatograph equipped with a Thermo Scientific™ Instant Connect Split/Splitless (SSL) Injector and a Thermo Scientific™ Instant Connect FID to assess the linearity for Class 1, Class 2A and Class 2B residual solvents.
This work evaluates the performance of the new Thermo Scientific™ TriPlus™ 500 Gas Chromatography Headspace (HS) Autosampler for the determination of residual solvent content in water-soluble and waterinsoluble pharmaceuticals according to the United States Pharmacopeia <467> method (USP).
This application note describes the analysis of residual solvents in accordance with USP method <467> using the Thermo Scientific™ TRACE™ 1310 GC, the new Thermo Scientific™ TriPlus™ 300 Headspace autosampler, and the Thermo Scientific™ Dionex™ Chromeleon™ chromatography data system (CDS) software. The method details the chromatographic system and analytical conditions to be used and addresses the acceptable limits for each solvent.