The Thermo Scientific™ Vanquish™ Flex UHPLC system is applied for the Related substance analysis of Caspofungin. The analysis was performed on the Thermofisher Scientific Acclaim C30 HPLC Column. The results obtained for the Resolution and theoretical plates met the criteria.
Reliable and highly reproducible chromatographic results were obtained when implementing the liquid chromatography-based impurity method from the Ph. Eur. monograph of metolazone.
The presented results show that Thermo Scientific™ Vanquish™ Core HPLC systems have excellent system-to system reproducibility when the sample preparation, eluent preparation, and LC column are identical. Users can rely on the fact that the performance of multiple Vanquish Core HPLC systems will be highly predictable and robust for routine methods in quality control labs when other variables are controlled.
To demonstrate how custom injection programs affect chromatographic parameters such as asymmetry, resolution, and efficiency of a selected EP method.
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of the related substances of ganciclovir. The analysis was performed on a Thermo Scientific BioBasic SCX HPLC column using the method described in the EP 9.0 monograph. The results obtained for resolution between the peaks due to ganciclovir and its impurity E met the criteria stated in the EP.
