Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.
The assay of hydroxyzine hydrochloride was performed on a Thermo Scientific Dionex UltiMate 3000 system with UV detection at 232 nm. The Thermo Scientific Hypersil GOLD aQ column was used to perform the assay with a run time of 25 minutes.
