The Thermo Scientific Dionex Ultimate 3000 HPLC system was applied for the reaction monitoring of fexofenadine and its impurities during the synthesis of fexofenadine API. The separation was performed on a Thermo Scientific Accucore PFP HPLC column resolution of 2.5 between fexofenadine and its meta isomer was achieved.
The Thermo Scientific HPLC system is applied for the analysis of a fexofenadine tablet. The separation is performed on a Thermo Scientific Hypersil GOLD HPLC column, with UV detection at 254 nm.
The Thermo Scientific Acclaim Polar Advantage (PA) HPLC column is used to separate fexofenadine and pseudoephedrine formulation in less than four minutes.
