Forensic toxicologists need an economical solution to screen for a virtually unlimited number of compounds in urine. Here we present a method for screening using a dilute-and-shoot approach with the Q Exactive Focus mass spectrometer and Thermo Scientific ToxFinder software. For forensic use only.
Forensic toxicologists face an ever-expanding list of compounds for analysis. This note presents work done using a next-generation triple quadrupole mass spectrometer with fast SRM acquisition speed for quantitation of 122 analytes in a single chromatographic run, where scan speed does not impact sensitivity or quantitative performance. Compounds analyzed include opiates, opioids, benzodiazepines, barbiturates, amphetamines, tricyclic antidepressants, illicit compounds, and more. For forensic use only.
The Thermo Scientific HPLC system is applied for the analysis of basic drugs. The separation is performed on a Thermo Scientific Acclaim 120 C18 column, with UV detection at 220 nm. This application is used as a routine lot qualification test for the Acclaim 120 C18 column stationary phase. Low silanol activity preserves the good peak shape for amitriptyline as the sample concentration decreases (amitriptyline mass for trace A is 1200 ng, for trace B is 400 ng, and for trace C 94 ng).
The Thermo Scientific HPLC system is applied for the determination of five antidepressants. The separation is performed on a Thermo Scientific Acclaim PolarAdvantage (PA) HPLC column, with UV detection at 220 nm.
The Thermo Scientific HPLC system is applied for the determination of doxepin in human plasma. The samples are prepared using Thermo Scientific SOLA HRP solid phase extraction (SPE) cartridges, and the separation performed on a Thermo Scientific Accucore C18 HPLC column. For Research Use Only. Not for use in diagnostic procedures.
