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Related substances analysis of cefadroxyl monohydrate using a C18 HPLC column as per EP 8.0 monograph method
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the related substances analysis of cefadroxyl monohydrate. The analysis was performed on a Thermo Scientific Syncronis C18 HPLC column using the method described in the EP 8.0. The results obtained for resolution and signal-to-ratio met the criteria stated in the EP. The results obtained for resolution between the peaks due to EP Impurity A and EP Impurity B was 15.5 (EP criteria of minimum 5.0) and signal-to-ratio of EP Impurity B (0.4 µg/mL) was 56 (EP criteria of minimum 10). A sample chromatography is attached.| Market: | Pharma |
| Keywords: | Cefadroxil, Cephalosporin Antibiotic, HPLC, UV detection, Syncronis C18 |
| Matrix: | N/A |
| Author: | Krishnarao Dara |
| Affiliation: | Thermo Fisher Scientific, APAC CoE Lab, Ahmedabad, India |
For Research Use Only. Not for use in diagnostic procedures.
