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Plasma Free Metanephrines Quantitation with Automated Online Sample Preparation and Liquid Chromatography-Tandem Mass Spectrometry
Description
Plasma free metanephrine (MN) and normetanephrine (NMN), collectively known as Pmets, are preferred biomarkers for pheochromocytoma for clinical research. LC-MS/MS has become widely used to measure Pmets because of its high analytical specificity. Although our recently reported method utilizing LC-MS/MS using IP-SPE and PGC column chromatography is fast and analytically sensitive, it can be further improved by automating the offline sample preparation with online sample preparation technology, which is more time- and cost-effective.| Market: | Clinical Research |
| Keywords: | TurboFlow Technology, TSQ Vantage MS, Metanephrine, Normetanephrine, MN, NMN, Pmets, Pheochromocytoma |
| Matrix: | Plasma |
| Author: | Xiang He, Marta Kozak |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
