Separation of Related Impurities from Vercuronium Bromide as per BP monograph.
DescriptionThe Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of Vercuronium Bromide. The separation was performed on a Thermo Scientific Acclaim Polar Advantage-II HPLC column using the method described in BP monograph. The results obtained for Resolution exceeded the criteria stated in the BP. Resolution between Vercuronium Bromide and Impurity-C was 8.97 ( met BP criteria of NLT 1.2), Resolution between Vercuronium Bromide and Impurity-F was 2.15 (met BP criteria of NLT 1.2) and Resolution between Vercuronium Bromide and Impurity-B was 10.78 (met BP criteria NLT 2.0).
|Keywords:||HPLC, UV detection, Acclaim Polar Advantage-II, Vercuronium Bromide|
|Affiliation:||Thermo Fisher Scientific, APAC CoE Lab, Ahmedabad, India|
For Research Use Only. Not for use in diagnostic procedures.