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USP 38 monograph: assay analysis of tetracycline hydrochloride using a C8 HPLC column
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the assay analysis of tetracycline hydrochloride. The separation was performed on a Thermo Scientific Acclaim 120 C8 HPLC column using the method described in the USP 38 monograph. The results obtained exceeded the criteria stated in the USP. Resolution between 4-epianhydrotetracycline hydrochloride and tetracycline hydrochloride peak was 3.5 (USP criteria of not less than 1.2). Relative retention time of 4-epianhydrotetracycline hydrochloride with respect to tetracycline hydrochloride peak was 0.82 (USP criteria about 0.9).| Market: | Pharma |
| Keywords: | Acclaim 120 C8, HPLC, UV detection, USP 38 monograph, Tetracycline hydrochloride, 4-epianhydrotetracycline hydrochloride |
| Matrix: | N/A |
| Author: | Manish Singh |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
