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EP 8.0 monograph: impurity determination of metronidazole using a C18 HPLC column
Description
The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of metronidazole and its impurities. The separation was performed on a Thermo Scientific Syncronis C18 HPLC column using the method described in the EP 8.0 monograph. The results obtained for resolution and tailing factor exceeded the criteria stated in the EP. Resolution between impurity A and metronidazole was 6.9 (EP criteria of not less than 2.0) and tailing factor for metronidazole was 1.0 (EP criteria not more than 2.0).| Market: | Pharma |
| Keywords: | HPLC, Syncronis C18, Metronidazole, UV detection, EP 8.0 monograph |
| Matrix: | N/A |
| Author: | Manish Singh |
| Affiliation: | Thermo Fisher Scientific |
For Research Use Only. Not for use in diagnostic procedures.
