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AN235: Determination of Oversulfated Chondroitin Sulfate and Dermatan Sulfate in Heparin Sodium Using Anion-Exchange Chromatography with UV Detection
Description
Heparin, a complex sulfated glycosaminoglycan, is a well-known anticoagulant used to stop or prevent blood from clotting in certain types of surgeries and dialysis treatments. In 2008, a galactosamine-based synthetic contaminant, called Oversulfated Chondrotin Sulfate (OSCS), was identified in Heparin as causing severe adverse affects and in some, death. The current USP 32 monograph from 2008 was upgraded to include chromatographic methods to detect OSCS and the natural contaminant, dermatan sulfate (DS). In this method, heparin, DS, and OSCS were separated by IC and detected at 202 nm.| Market: | BioPharma |
| Keywords: | heparin, IonPac AS11 column, oversulfated chondroitin, Dermatan sulfate, Heparin sodium, OSCS, Oversulfated chondroitin sulfate, USP L61 column, DS |
| Matrix: | Heparin |
For Research Use Only. Not for use in diagnostic procedures.
