TN44: The Determination of Trace Anions in Concentrated Phosphoric Acid

Instrument Type: IC

The determination of trace anions in phosphoric acid is hampered by a large excess of phosphate ion. Diluting the concentrated sample overcomes the problem of a large concentration of the interfering matrix ion, but lacks the required sensitivity for the contaminant ions of interest. An improved method for determining trace anions in concentrated phosphoric acid has been developed to overcome this problem. This Technical Note describes the theory, set up, and analytical procedure for the determination of chloride, nitrate, and sulfate at sub-mg/L (ppm) levels in 85% (w/w) phosphoric acid.

AN106: Ion (Ion Exclusion) Chromatography in the Pharmaceutical Industry

Instrument Type: IC

Ion Chromatography is a simple and accurate technique for the analysis and quantification of charged species. This application note describes the use of ion exchange chromatography and ion exclusion chromatography in the pharmaceutical industry for the analysis of ions in ingredients and final products. The topic of cleaning validation is also discussed as it applies to charged species. Here shows the separation of several weak organic acids by ion exclusion chromatography using an IonPac ICE-AS6 column.

AN409: Fast Determination of Acrylamide in Food Samples Using Accelerated Solvent extraction Followed by Ion Chromatography with UV or MS Detection

Instrument Type: IC

This fast determination of acrylamide method consists of a fast, automated extraction method, which finish extraction in 20 min using accelerated solvent extraction using pure water, water with 10 mM formic acid, or acetonitrile. The extracts were then directly analyzed by ion chromatography (IC) using a 4-mm ion-exclusion column and both UV and MS detection. Results were obtained for acrylamide in french fries, potato chips, and crisp bread.