Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/L Level Utilizing Online Sample Preparation with LC-MS/MS

Instrument Type: LCMSMS

There is growing environmental concern regarding the health impact of trace levels of pharmaceuticals and personal care products (PPCPs) in water resources. In response, the U.S. Environmental Protection Agency (EPA) published Method 1694, which determines dozens of PPCPs in water, soil, sediment, and biosolids by HPLC-MS/MS. We demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.

Screening method for fluoroquinolones using an advanced UHPLC column and system combination.

Instrument Type: UHPLC

To provide an application for the analysis of fluoroquinolones using the Thermo Scientific™ Hypersil GOLD VANQUISH™ 1.9 µm column and Thermo Scientific™ Vanquish H™ UHPLC system

USP 38 monograph - impurities test for levofloxacin using a C18 HPLC column

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the analysis of levofloxacin and its impurities. The separation was performed on a Thermo Scientific Acclaim 120 C18 HPLC column using the method described in the USP 38 monograph. The results obtained for % relative standard deviation and signal to noise ratio exceeded the criteria stated in the USP. Relative standard deviation for system suitability solution was 0.1% (USP criteria of not more than 1.0%) and signal to noise ratio for sensitivity solution was 58 (USP criteria not less than 10).