The Thermo Scientific HPLC system is applied for the analysis of purines and pyrimidines. The separation is performed on a Thermo Scientific Hypercarb column, with an ultra high temperature gradient.

The Thermo Scientific HPLC system is applied for the analysis of basic drugs. The separation is performed on a Thermo Scientific Acclaim 120 C18 column, with UV detection at 220 nm. This application is used as a routine lot qualification test for the Acclaim 120 C18 column stationary phase. Low silanol activity preserves the good peak shape for amitriptyline as the sample concentration decreases (amitriptyline mass for trace A is 1200 ng, for trace B is 400 ng, and for trace C 94 ng).

The Thermo Scientific HPLC system is applied for the separation of basic compounds. The separation was performed using a Thermo Scientific Accucore RP-MS column in under 3 minutes, with UV detection at 215nm.

The Thermo Scientific HPLC system is applied for the determination of benzodiazepines. The separation is performed on a Thermo Scientific Hypersil GOLD Phenyl 1.9 µm UHPLC column, with UV detection at 254 nm.

The Thermo Scientific HPLC system is applied for the analysis of a phenone test mix. The separation is performed on a Thermo Scientific Hypersil GOLD HPLC column, with UV detection at 254 nm.