Aluminum-containing compounds are used extensively in cosmetics, prescription pharmaceuticals, and OTC drug products. In this application note, we report the validation of an IC method for the determination of aluminum in OTC formulations using a Dionex IonPac CS10 analytical column and postcolumn derivatization with Tiron, followed by UV absorbance detection at 310 nm. The method was evaluated in terms of linearity, precision, accuracy, ruggedness, and limit of quantitation for aluminum. The method was evaluated with antacids and deodorants. An ICS-6000 can be used for this application.

Three methods are presented here for the determination of Chromium in various matrices. Method A utilizes a postcolumn reaction (PCR) with a color reagent. It is a very selective and sensitive method, allowing determination of Cr(III) & Cr(VI) at ppb levels. Method B also utilizes a PCR, but determines Cr (VI) only. It is used for industrial waste waters, analyzing samples that have undergone standard oxidation. Method C allows the determination of inorganic anions in addition to chromate by chemically suppressed conductivity. Please refer to AN1116, AU144, AU165 and AU179 for updated methods.

This application update describes the determination of the metal cyanide complexes of iron, cobalt, silver, gold, copper, and nickel in solid wastes by anion-exchange chromatography with UV absorbance detection. Metal cyanide complexes are solubilized and recovered by an alkaline extraction procedure (SW846 Method 9013) prior to chromatographic analysis. Two analytical approaches are available depending on the concentration of metal cyanides expected in the leachate; the two methods differ only in how the sample is injected.

Metal cyanide complexes are of environmental concern because they release cyanide upon dissociation. The metal cyanide complexes of silver, gold, copper, nickel, iron, and cobalt are separated on an IonPac AS11 column and quantified by measuring their absorbance at 215 nm. Use of the 2-mm AG11/AS11 column set provides different selectivity, lower eluent use, and better solvent compatibility than the AG5/AS5 column set featured in AN 55. The method was evaluated for reproducibility, linearity, accuracy, precision, and spike recovery from various matrices.

In this application note, an improved IC method is described for the determination of metal cyanide complexes in environmental waters. The metal cyanide complexes of silver, gold, copper, nickel, iron, and cobalt are separated on an anion-exchange column and quantified by measuring their absorbance at 215 nm. Sensitivity for most of the metal cyanide complexes is improved by over two orders of magnitude, compared to a direct injection, by preconcentrating metal cyanide complexes from a large sample volume onto a trap column before separation.