Quantitation of Seven Designer Cathinones in Urine Using Q Exactive Mass Spectrometer

Instrument Type: LCMSMS

Substituted cathinones, or “Bath Salts,” have become the latest abused designer drugs. Based on cathinone, a substance found in the African Catha edulis (khat) plant, substituted cathinones are stimulants with amphetamine- and cocaine-like effects. We describe an HPLC-MS method for the forensic toxicological analysis of the three Schedule I cathinones: MDPV, methylone and mephedrone, as well as other substituted cathinones: methedrone, ethylone, butylone and naphyrone in urine with limits of quantitation (LOQs) of 0.5 ng/mL. For forensic use only.

Qualitative and Quantitative Analysis of Contaminants of Emerging Concern in Biosolids Using a Dilute and Shoot UHPLC-Orbitrap MS Method

Instrument Type: LCMSMS

We develop an HRAM-based LC-MS/MS workflow to quantitatively analyze contaminants of emerging concern (CECs) in biosolids samples and to screen for 381 non-targeted CECs. Unlike LC-QQQ-MS/MS, the Fisher Scientific Exactive Plus Orbitrap full-scan high-resolution, accurate-mass (HRAM) mass spectrometry provides not only quantitative data for targeted compounds but also information on the non-targeted compounds, such as environmental transformation by-products, for possible environmental loadings and ecological effects that would not be available in a targeted assay.