Related substances analysis of sulfamethoxazole using a C8 HPLC column as per EP 8.0 monograph method

Instrument Type: HPLC

The Thermo Scientific Dionex UltiMate 3000 LC system is applied for the related substances analysis of Sulfamethoxazole. The analysis was performed on a Thermo Scientific Syncronis C8 HPLC column using the method described in the EP-8.0 monograph. The results obtained for peak resolution and relative retention times exceeded the criteria stated in the EP. Resolution between sulfamethoxazole and Impurity-A was 5.7 (EP criteria of not less than 3.5).

Enhanced gradient resolution of sulfa drugs

Instrument Type: HPLC

The Thermo Scientific HPLC system is applied for the analysis of sulfa drugs. The separation is performed using a Thermo Scientific Acclaim PolarAdvantage column, with UV detection at 254 nm.

Purity and mass determination using Thermo Scientific Accucore aQ HPLC columns: a column lifetime study

Instrument Type: HPLC

A fast and reliable separation for quality control of small molecule drug candidates is demonstrated using Thermo Scientific Accucore aQ HPLC columns. The method run time was 3.25 minutes with each compound adequately resolved. The excellent peak shape was maintained for more than 11000 injections.