Routine, Targeted and Non-Targeted Analysis of Environmental Contaminants of Emerging Concern - Development and Validation of a UHPLC Orbitrap MS Method

Instrument Type: LCMS

Contaminants of emerging concern (CEC) in the environment are generally described as compounds that are unknown or unrecognized, undetected or not routinely monitored, and represent a diverse group of chemicals that may pose a risk to human health and the environment. Due to limited analytical capability and available resources , monitoring of CECs has been focused on selected analytes rather than a holistic approach. We describe a new analytical method that can be used in the quantitative analysis of 61 targeted and 312 non-targeted CECs.

Analysis of Diquat and Paraquat Using UHPLC Orbitrap MS - Method Development, Matrix Effects and Performance

Instrument Type: LCMS

We investigate the effect of UHPLC mobile phases and operational parameters of a Orbitrap MS system used in the analysis of quaternary ammonium herbicides paraquat (PQ) and diquat (DQ). This includes separation optimization on a Thermo Scientific Acclaim Trinity Q1 column which was specifically designed for this application. Based on results obtained from this study, a method was developed for the unambiguous identification of PQ and DQ in environmental water samples with the ability to deliver analytical data with superior SNR, high precision and accuracy.

Determination of Fusarium Mycotoxins in Wheat, Maize and Animal Feed Using an Online TurboFlow and Orbitrap LC/MS Method

Instrument Type: LCMSMS

We describe a method using the Thermo Scientific Transcend TLX system with TurboFlow technology, which combines chromatography with high-resolution mass spectrometry, was developed and validated in house for the determination of deoxynivalenol, zearalenone, T-2 toxin, HT-2 toxin, fumonisins B1 and B2 in maize (corn), wheat and animal feed. Linearity range, limit of detection (LOD), limit of quantification (LOQ), recovery, repeatability, intermediate precision and accuracy were established by analysis using certified reference materials and the performance of successful proficiency testing.