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AN269: Identification and Quantification at ppb Levels of Common Cations and Amines by IC-MS

Instrument Type: ICMS

The work shown here demonstrates the use of IC-MS for the determination of six commonly found cations and selected amines on an IonPac CS12A-5µm column. Confirmatory information was obtained using full-scan MS spectra showing positively charged cation species and characteristic adduct patterns. Quantification was achieved using selected ion monitoring (SIM) acquisitions for each target analyte.

AN1057: Determination of Methylamine in Drug Products

Instrument Type: IC

Methylamine or monomethylamine (MMA) is widely used in different stages of the preparation of various drug substances and may be retained in the drug substance as process-related or degradation impurities. The work shown here uses a RFIC system with suppressed conductivity detection to determine MMA in drug products. This method uses a Thermo Scientific™ Dionex™ IonPac™ CS19 analytical column with methanesulfonic acid (MSA) eluent produced by an eluent generator. The method separates MMA from other cations typically present in drug products.