USP 467 analysis of residual solvents using GC-FID with headspace

Instrument Type: GC

The Thermo Scientific TRACE GC Ultra is applied for the analysis of residual solvents by USP method 467. The separation was performed on a Thermo Scientific TRACE TR-V1 GC column, with flame ionization detection.

AU163: Determination of Trace Anions in Organic Solvents Using Matrix Elimination and Preconcentration

Instrument Type: IC

Anion contamination introduced during manufacturing processes can ruin semiconductor devices, and therefore trace contaminants in solvents are a concern. This method successfully determines trace anions (high ng/L to low μg/L) in isopropyl alcohol, methanol, acetone, and n-methyl-2-pyrrolidone by matrix elimination. Results show improved method detection limits (MDLs) using 60% smaller sample injections. The method easily meets the Semiconductor Equipment and Materials International (SEMI®) specifications for solvents, with typically 100- to 2800-fold lower MDLs than the SEMI specifications.

AN201: Determination of Chloride and Sulfate Methanol Using Ion Chromatography

Instrument Type: IC

This application note presents a simple and direct approach for determining chloride and sulfate in methanol using a Reagent-Free™ IC system with eluent generation (RFIC-EG™ system). Chloride and sulfate are determined in less than 12 min using an IonPac® AS24 column with an electrolytically generated potassium hydroxide eluent and suppressed conductivity detection. The linearity, limits of quantitation, and precision of chloride and sulfate determination in methanol are demonstrated. This RFIC-EG system method delivers a fast and automated assay of chloride and sulfate in methanol.