Approximately 50% of all drugs on the market are developed in salt forms. IC with suppressed conductivity detection plays an important role in the salt selection process to establish correct molecular mass of the entity in early stages of drug development. This study describes the determination of inorganic anions (a) and cations (b) in two different drugs using the capillary Thermo Scientific Dionex ICS-5000 system.

This study describes the determination of inorganic anions and cations in drinking water using the Thermo Scientific Dionex ICS-5000 capillary IC system. Here shows the determination of inorganic cations in drinking water using Dionex IonPac CS12A capillary column.

Inorganic cations were determined in municipal wastewater samples using a high pressure capillary IC system. All six cations were separated on IonPac CS16 capillary column at 30 mM MSA and 40 C. The high pressure capabilities of the ICS-5000+ capillary IC system were demonstrated by using flow rates at 3x of the typical capillary flow rate, 30 uL/min. The separation at the standard flow rate of 10 uL/min is also shown. An ICS-6000 can be used for this application.

Morpholine and ammonium are used as additives in power plant waters. Morpholine acts as a corrosion inhibitor, whereas ammonium is used to control pH. In this matrix, it is critical to determine the presence of inorganic cation contaminants. This method uses the IonPac CS14 column to quantify trace concentrations of lithium, sodium, potassium, magnesium, and calcium in the presence of high levels of ammonium and morpholine. Acetonitrile can be added to the eluent to improve peak shape and optimize resolution for some of the cations of interest.

Morpholine and ammonium are used as additives in power plant waters. Morpholine acts as a corrosion inhibitor, whereas ammonium is used to control pH. In this matrix, it is critical to determine the presence of inorganic cation contaminants. This method uses the IonPac CS14 column to quantify trace concentrations of lithium, sodium, potassium, magnesium, and calcium in the presence of high levels of ammonium and morpholine. Acetonitrile can be added to the eluent to improve peak shape and optimize resolution for some of the cations of interest.