TN120: Fast Separations of Counter Ion in an Allergy Drug Tablet Using High-Pressure Capillary IC

Instrument Type: IC

This application demonstrates the advantages of high pressure capillary IC using the high efficiency Dionex IonSwift MAX 200 capillary size anion-exchange monolith column to provide high sample throughput by simply increasing the flow rate on a high pressure capable Dionex ICS-5000+ HPIC capillary IC, resulting in saving time and money. An ICS-6000 can be used for this application.

AN2967: Implementation of a Walk-Up High-Pressure Capillary Ion Chromatograph for the Fast Separation of Pharmaceutical Relevant Inorganic Anions (allergy tablet)

Instrument Type: IC

The API counter ion impacts the drug’s efficacy, solubility, and toxicity, and therefore counter ion determinations are important to pharmaceutical companies during all stages of product development and as part of product quality monitoring. In this example, the chloride counter ion is determined in a water extract of a pharmaceutical drug tablet designed for the treatment of seasonal allergic reactions. Here fast chloride determinations were demonstrated on IonSwift MAX-200 capillary column using a walk-up high pressure capillary IC system.