AN116: Quantification of Anions in Pharmaceuticals (Carbonate/Bicarbonate Eluent)

Instrument Type: IC

The United States Food and Drug Administration (U.S. FDA) and regulatory agencies in other countries require that pharmaceutical products be tested for composition. This Application Note describes the use of two anion exchange columns, IonPac AS14 and IonPac AS11 with suppressed conductivity detection to analyze common anions in pharmaceutical formulations. Here we demonstrate that the IonPac AS14 column, using an isocratic carbonate/ bicarbonate eluent, resolves common inorganic anions in pharmaceutical products.

AN116: Quantification of Anions in Pharmaceuticals (Hydroxide Eluent)

Instrument Type: IC

The United States Food and Drug Administration (U.S. FDA) and regulatory agencies in other countries require that pharmaceutical products be tested for composition. This Application Note describes the use of two anion exchange columns with suppressed conductivity detection to analyze common anions in pharmaceutical formulations. Here demonstrate that the IonPac AS11 resolves, in the same injection, common inorganic anions such as fluoride, chloride, bromide, sulfate, nitrate, and phosphate, as well as common organic anions such as benzoate, sorbate, citrate, and saccharin.