A Strategy for an Unknown Screening Approach on Environmental Samples Using HRAM Mass Spectrometry

Instrument Type: LCMS

The analysis of food and environmental samples for contaminants by LC-MS has become a quick and cost-effective routine application when run in a targeted fashion, but this method disregards events or circumstances not taken into account beforehand. We describe a method by one data set can serve for routine high throughput quantitative analysis and for versatile non-targeted investigations in a highly automated manner.

Qualitative and Quantitative Analysis of Contaminants of Emerging Concern in Biosolids Using a Dilute and Shoot UHPLC-Orbitrap MS Method

Instrument Type: LCMSMS

We develop an HRAM-based LC-MS/MS workflow to quantitatively analyze contaminants of emerging concern (CECs) in biosolids samples and to screen for 381 non-targeted CECs. Unlike LC-QQQ-MS/MS, the Fisher Scientific Exactive Plus Orbitrap full-scan high-resolution, accurate-mass (HRAM) mass spectrometry provides not only quantitative data for targeted compounds but also information on the non-targeted compounds, such as environmental transformation by-products, for possible environmental loadings and ecological effects that would not be available in a targeted assay.