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AN1078: Rapid Separation of Benzenesulfonate in Amlodipine Besylate by High-Pressure IC

Instrument Type: IC

As a part of this application, a Dionex IonPac AS18-4 μm Analytical column (2×150 mm) was evaluated for the determination of benzenesulfonate in amlodipine besylate, to increase sample throughput. This column uses the same ion-exchange chemistry as the IonPac AS18 column described in this study but with smaller substrate particles. The smaller particle size provides higher peak efficiencies and improved resolution. This and the Dionex ICS-5000+ HPIC system allow higher flow rates to be used that produce faster run times and increased productivity. An ICS-6000 can be used for this application.

AN1078: Determination of Benzenesulfonic Acid Counterion in Amlodipine Besylate by Ion Chromatography

Instrument Type: IC

This study demonstrates the determination of benzenesulfonate in amlodipine besylate using an electrolytically generated potassium hydroxide eluent with a hydroxide-selective Dionex IonPac AS18 anion exchange column and suppressed conductivity detection. This method provides a simple and reliable approach to determine the counter ion in the drug substance.