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API and counterions in Adderall using multi-mode liquid chromatography with charged aerosol detection

Instrument Type: HPLC-CAD

This work demonstrates the determination of the API (amphetamine) and counterions (aspartate, saccharin and sulfate) in a medicine Adderall within a single analysis using a Thermo Scientific Acclaim Trinity P2 column and Thermo Scientific Dionex Corona Veo Charged Aerosol Detector (CAD).

Improved analysis of API and counterions in Adderall

Instrument Type: HPLC-CAD

The Thermo Scientific UltiMate 3000 HPLC system is applied for the analysis of the API (active pharmaceutical ingredient) amphetamine and its counterions. The separation is performed using a Thermo Scientific Acclaim Trinity P1 column, with both UV and charged aerosol detection. Amphetamine and saccharin respond to UV detection; aspartate, saccharin and sulfate respond to charged-aerosol detection. Note that metal contamination will cause peak tailing, and before use, the column should be cleaned with a chelating agent at pH 4.