The Thermo Scientific Accucore Biphenyl column offers alternative selectivity to a C18 column for clinical research. This high-resolution column separates isomers and steroids utilizing superior combination of hydrophobic, aromatic, and polar selectivity.
A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
We present a a liquid chromatography – high-resolution, accurate mass (LC-HRAM) methodology using Orbitrap technology as a sensitive, accurate, and reliable alternative to the use of triple quadrupole mass spectrometers in the quantification of hormones in drinking water according to EPA guidelines. By using different scanning modes within the Q Exactive MS, quantitation on precursor ions and identification of fragments ions are possible. These scanning modes can possibly be used for compliance monitoring in place of a triple quadrupole MS.
Androgenic-anabolic steroids (AAS) are drugs which mimic effects of testosterone and dihydrotestosterone in the human body. They increase protein synthesis within cells which results in buildup of cellular tissue, especially in muscles. Use of anabolic steroids by athletes to increase body weight is referred to as doping and is banned by major sporting bodies. In this work we implemented Thermo Scientific Q Exactive ultra high resolution mass spectrometer to ensure high method specificity and sensitivity.
Analysis of testosterone in female and juvenile plasma samples for research requires an analytically sensitive method with a limit of quantitation of at least 10 pg/mL. Liquid chromatography coupled with mass spectrometry (LC/MS), an analytically sensitive and selective technique, is widely accepted for testosterone analysis in complex matrices such as human serum or plasma.
