A robust, sensitive, and reliable multi-residue LC-MS/MS method workflow solution that uses the Thermo Scientific TSQ Altis triple quadrupole mass spectrometer provides analysis and quantitation of more than 160 veterinary drugs with the Thermo Scientific VetDrugs Explorer Collection solution in salmon (fillet), bovine muscle, and milk. The complete instrument and data processing method including SRM settings is included with the VetDrugs Explorer Collection start-to-finish workflow solution. In 17 minutes, the target veterinary drugs were detected and quantified in food matrices.
Sulfonamides are used widely as anti-inflammatory medications for humans and livestock, and have recently become compounds of interest to regulatory agencies worldwide. Triple stage quadrupole LC-MS systems are often used for highly sensitive quantitative analyses of environmental pollutants. Performance of the LC-MS and sample pre-treatment are 2 critical factors that determine efficiency and accuracy in detection of low concentrations of pollutants in environmental samples. We describe a method for the quantitative analysis of sulfonamide antibiotics using EQuan.
The Thermo Scientific HPLC system is applied for the analysis of sulfa drugs. The separation is performed using a Thermo Scientific Acclaim PolarAdvantage column, with UV detection at 254 nm.
